Text font is exploded into 2D contours and these contours are then extruded. For 3D, extrusion height and draft angle is defined. You can write text, select text height or text font. All rights reserved.3D Comprehensive Shapes Creating and Editing 3D TextsģD texts extruded into space can be defined and edited the same way as 2D texts. This study provides the first core-shell MN patch for controlled months-long drug release and supports the development of long-acting contraception using a simple-to-administer, twice-per-year MN patch.Ĭontraception Core-shell structure Long-acting Microneedle Sustained release.Ĭopyright © 2022 Elsevier B.V. A monolithic MN patch formulated with the same LNG and PLGA core, but without the rate-controlling PLLA shell and PLA cap had a larger LNG burst release of 22.6 ± 2.0% and achieved LNG release for just 2.1 ± 0.2 months. The core-shell design limited the initial 24 h burst release of LNG to 5.8 ± 0.5% and achieved roughly zero-order LNG release for 6.2 ± 0.1 months in vitro. Upon application to skin, the core-shell MNs utilized an effervescent interface to separate from the patch backing within 1 min. In this approach, LNG was encapsulated in a poly(lactide-co-glycolide) (PLGA) core surrounded by a poly(l-lactide) (PLLA) shell and a poly(D,L-lactide) (PLA) cap that were fabricated by sequential casting into a MN mold. To achieve zero-order release, we developed a novel core-shell MN patch where the shell acts as a rate-controlling membrane to delay release of a contraceptive hormone, levonorgestrel (LNG), for 6 months. Microneedle (MN) patches enable simple self-administration and have previously been formulated for 1-2 months' controlled release of contraceptive hormone using monolithic polymer/drug MN designs having first-order release kinetics. There is a tremendous need for simple-to-administer, long-acting contraception, which can increase access to improved family planning.
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